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Fasting stimulates autophagy

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06 Nov 2012 16:07 #13549 by Hungry Caveman
Hungry Caveman created the topic: Fasting stimulates autophagy

The Fast Doctor wrote: There is very little if any research available in this respect dear Stu. I can think of a few mechanisms:

1. You removed the toxins (or at least some of them) that impaired this function.

2. Your instinct tells you that when the famine is over, it's time to procreate. Thus the breaking of the fast rather than the fast itself may be the factor to give credit to.

3. Being able to do a fast makes you psychologically younger, because it confirms that your body is still capable of performance.

4. During a fast, there's about 25% more blood flow available to the rest of your body, as the digestive system goes "on holiday". This blood flow is precisely what drugs like Viagra tries to imitate.. only those have side effects, and actually "robs" your digestive system of blood flow. When fasting, the digestive system does not need the flow..

5. Fasting makes you feel you have conquered the weaknesses of your physical body.. thus you also get to be "in charge" of so many other physiological functions.

I can think of a few more if you give me time...

André


This is a truly an excellent answer to the question.

To this I might add this. Fasting stimulates a process called autophagy. Autophagy is Greek for self digestion. When cells are starved they will digest their own junk and garbage for energy to survive. This is one way the body cleans itself at the cellular level when the body fasts. Cells that are cleaned this way are rejuvenated and repaired and function as much younger cells. Autophagy is age reversal at the cellular level.

So it is not surprising that fasting might make you feel more frisky! :evil:

-Caveman

I believed until I realized that God remains not in the sky, but on Earth in people who are able to be victorious over themselves.
-Porfiry Ivanov

loseweightgetyounger.com

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07 Nov 2012 16:08 #13579 by Hungry Caveman
Hungry Caveman replied the topic: Fasting stimulates autophagy
Autophagy May Promise Age Reversal at the Cellular Level


Attachment Autophagicpathay.JPG not found




Autophagy (pronounced something like oh TUFF ah gee) sounds like a disease, but autophagy is a normal biological process. During the process, organelles called lysosomes break down waste products inside the cells. Lysosomes break down worn-out organelles, digest food particles, and destroy viruses and bacteria.

Autophagy is Greek for self eating. It has been showed through research that when a cell is starved it will, before it dies, start digesting itself. The good news is that it will start digesting the above-mentioned garbage in the cell first. This garbage accumulates as the cell ages and so the process , in theory, actually reverses the aging of the cell and improves its heath significantly.

It is believed that from an evolutionary perspective this process developed to protect us from starvation. The accumulated junk in our cells can be used as energy after most of our fat reserves are gone.

But when the cells are cleaned of junk they become much healthier cells and do in fact resemble much younger cells in appearance and function. Autophagy is age reversal at the cellular level.

Obviously this process would appear to have the potential to reverse aging.

Very recent research has also demonstrated that exercise also stimulates this process.

I am proposing a treatment model for disease, including aging, that would involve self induced “autophagy fasting” using long fasts in combination with as much exercise as is possible to stimulate the process to the maximum. This stimulation would be taken to the point that the body gets something of a major overhaul and reverses the aging process at the cellular level. Other independent researchers have already noted that in clinical studies fasting seems to result in remarkable rejuvenation of “protoplasm” and making the protoplasm appear more youthful than before the fast.

But this is very strong medicine and I have compared it to chemo therapy or radiation therapy used to treat cancer. Like chemo therapy or radiation therapy it can make the patient sick. This treatment model also sees aging not as a natural process but as a disease that can be treated just as cancer can be treated.

To date I am patient number one (please see my before and after pictures at www.loseweightgetyounger.com/index.htm ) and these ideas, based only on my own experience and research, remain largely theoretical and anecdotal. I am not a medical doctor and my experimentation on myself is done without medical supervision.

Also I should add that based on my own experience and research I would add to “autophagy fasting” and exercise, a third element which may be just as important for stimulating autophagy and protecting the patient from serious illness. I discuss this in another article, Rest and the Absence of Stress.

-Caveman

I believed until I realized that God remains not in the sky, but on Earth in people who are able to be victorious over themselves.
-Porfiry Ivanov

loseweightgetyounger.com
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07 Nov 2012 16:31 - 07 Nov 2012 16:33 #13580 by Ockeghem
Ockeghem replied the topic: Fasting stimulates autophagy

Hungry Caveman wrote: Autophagy May Promise Age Reversal at the Cellular Level


Attachment Autophagicpathay.JPG not found




Autophagy (pronounced something like oh TUFF ah gee) sounds like a disease, but autophagy is a normal biological process. During the process, organelles called lysosomes break down waste products inside the cells. Lysosomes break down worn-out organelles, digest food particles, and destroy viruses and bacteria.

Autophagy is Greek for self eating. It has been showed through research that when a cell is starved it will, before it dies, start digesting itself. The good news is that it will start digesting the above-mentioned garbage in the cell first. This garbage accumulates as the cell ages and so the process , in theory, actually reverses the aging of the cell and improves its heath significantly.

It is believed that from an evolutionary perspective this process developed to protect us from starvation. The accumulated junk in our cells can be used as energy after most of our fat reserves are gone.

But when the cells are cleaned of junk they become much healthier cells and do in fact resemble much younger cells in appearance and function. Autophagy is age reversal at the cellular level.

Obviously this process would appear to have the potential to reverse aging.

Very recent research has also demonstrated that exercise also stimulates this process.

I am proposing a treatment model for disease, including aging, that would involve self induced “autophagy fasting” using long fasts in combination with as much exercise as is possible to stimulate the process to the maximum. This stimulation would be taken to the point that the body gets something of a major overhaul and reverses the aging process at the cellular level. Other independent researchers have already noted that in clinical studies fasting seems to result in remarkable rejuvenation of “protoplasm” and making the protoplasm appear more youthful than before the fast.

But this is very strong medicine and I have compared it to chemo therapy or radiation therapy used to treat cancer. Like chemo therapy or radiation therapy it can make the patient sick. This treatment model also sees aging not as a natural process but as a disease that can be treated just as cancer can be treated.

To date I am patient number one (please see my before and after pictures at www.loseweightgetyounger.com/index.htm ) and these ideas, based only on my own experience and research, remain largely theoretical and anecdotal. I am not a medical doctor and my experimentation on myself is done without medical supervision.

Also I should add that based on my own experience and research I would add to “autophagy fasting” and exercise, a third element which may be just as important for stimulating autophagy and protecting the patient from serious illness. I discuss this in another article, Rest and the Absence of Stress.

-Caveman


Caveman,

I don't disagree with anything you have written here. In fact, I have believed in the benefits of fasting and exercise (including age-reversal) occurring at the cellular level for about six or seven years. It's one of the reasons that I continue to run during fasting and why I began rebounding (intense jumping on a trampoline = Al Carter's 'Reboundology') many years ago, since rebounding is primarily a cellular exercise, with each cell being stressed to the point that they become much stronger as a result. The circulatory, lymphatic, muscular, and skeletal systems greatly benefit from rebound exercise. Add fasting to this, and you have in my estimation a win-win scenario. :)

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30 Apr 2013 00:19 #16415 by ilovefasting
ilovefasting replied the topic: Fasting stimulates autophagy
Hungry Caveman

This report doesn't "push" me to do fasting more like "pull" me toward fasting, I love to know the details of what happens on fasting, because the more I know, the more it seems to make sense all over the place. I just need to start adding exercise to the game...

thanks for sharing

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