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A comprehensive description of ketosis.

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02 Dec 2007 23:36 #310 by Andrew
Andrew created the topic: A comprehensive description of ketosis.
Currently I'm trying to get my head around exactly how ketosis works. As in how the ketones are made and how they are used exactly- also if there is any difference between ketosis in fasting and fat burning.

Most articles I've been reading recently seem vague on the actual process, just saying that the fat cells break down into ketones.. but in a fat-burning article I just read it says that the Free Fatty Acids from the fat cells enter the liver which makes the ketones. This makes more sense than the other description which makes the process just seem like a spontaneous reaction rather than a normal bodily process.

Does anyone know where I can read a full description of the process of ketosis? From the point where the body runs out of outside fuel and starts burning fat short term during exercise, and also long term when fasting. I would assume that during exercise the fat is burning mostly for immediate energy needs whereas the body in ketosis during a fast has far more needs to satisfy in the long term and I would really like to understand this process a lot more.

Andrew.

\\"Truth is often painful, but ignorance is never bliss.\\"

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20 Jan 2008 19:17 #405 by TheFastDoctor
TheFastDoctor replied the topic: Re:A comprehensive description of ketosis.
Hope I can supply a few clues, although the exact biochemical processes of ketosis has not been fully unravelled.. probably because it will not benefit the Pharmaceutical industry.

There are 2 main types of fat involved: Cholesterol and Triglycerides.

The former is a Steroid (the same basic structure as cortizone, estrogen, vitamin D, Testosterone, etc.) and is also used to make cell membranes and insulate nerves from each other, preventing \"short circuits\". It is an \"aromatic\" molecule, consisting of carbon \"rings\".

The latter is an \"aliphatic\" molecule, that is, it does not contain ring structures, but is based on Glycerol, which is practically half a blood sugar molecule: 3 carbons in a string. On each of these, there are long \"fatty acids\" which is why we call them Tri (3) Glycer (ol) Ides.. When these are needed for energy, the Glycerol is parted from the fatty acids, and 2 of them pair up to make blood sugar (glucose). The fatty acids is turned into Ketones and yes, the liver can do so quite effectively but there is a lot of evidence that other cells in the body also has this ability. In people who haven't fasted for a long time, however, the other cells may have \"forgotten\" how to (their relevant enzymes are not active) which is why most are made in the liver during experiments.

Any good Biochemistry book should explain the processes in detail although many don't simply because it is considered irrelevant in disease based \"health care\".

André

All my posts are "generic", based on my opinions and experiences only and are not intended to replace the advice of your own licensed medical practitioner.
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20 Jan 2008 23:33 #412 by Andrew
Andrew replied the topic: Re:A comprehensive description of ketosis.
Thanks Andre that was exactly what I was after and what I couldn't find in my internet research anyway. I will have a look at the library next chance I get and see if I have any luck there though.

Your explanation also helps explain why essential fatty acids are so important for nervous disorders.

Andrew.

\\"Truth is often painful, but ignorance is never bliss.\\"

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15 Apr 2008 04:36 #668 by TheFastDoctor
TheFastDoctor replied the topic: Re:A comprehensive description of ketosis.
Yes Andrew, these EFA's.. it is assumed in most physiology studies that there are certain amino acids (protein bulding blocks) and Fatty Acids that we cannot produce from other sources.. they are called \"Essential\".

Some craftily marketing ploys exploit our limited insights and knowledge to concentrate on one nutrient or group of nutrients and extoll their greatness in isolation. This is wrong. We need our nutrients in a balance that only whole natural foods can supply.

I have yet to find a nutritional \"deficiency\" even in a fruitarian. We do, however, see a lot of nutritional excesses all the time. You rightly derive from this that I am not a fan of \"supplements\" at all. They are there only for the commercial interest of the manufacturer.

The only \"manufacturer\" with no ulterior motives is \"Mother Nature\".. and she will guide you to the appropriate foods as long as you select them from her pantry.

André

All my posts are "generic", based on my opinions and experiences only and are not intended to replace the advice of your own licensed medical practitioner.
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