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Adipose toxicity

27 Oct 2014 22:46 #23847 by david
david created the topic: Adipose toxicity
Dear Doctor time permitting could you comment on this query which was copied from the monthly themed fast thread. Thank you :)

Loquat: I believe healing accelerates after most of the visceral fat has been used up. It's a mistake to regard visceral fat as inert or harmless. It is metabolically toxic coz it produces a group of hormone disruptors called adipokines, which carry serious health risks. Most of those risks either disappear or at least are greatly reduced when the fat is gone. Once balance is restored to your endocrine (hormone) system, your body can properly start healing itself.

David: Loquat Please enlighten me is it the toxic waste stored in the visceral fat that is toxic or the fat itself?

Loquat: David - As you know, I'm no expert - but that's never stopped me venturing an unqualified opinion before! So here goes, subject to any possible correction made by the good Doc himself. Basically, it's a double-whammy. Both are responsible for oxidative stress, but via different routes.

Firstly, most of the environmental toxins that enter your body (heavy metals, plastics, pesticides, atmospheric pollutants, etc) end up in your fat deposits. The reason for this is that most of them are fat soluble, and therefore not so easily excreted through the urinary system, etc. That's one of the main reasons why, when we fast, we often feel so lousy in the first couple of weeks. That's your body telling you it's having to deal with some particularly nasty stuff while that fat store is being depleted.

And as if that's not enough, the fat itself is actively producing these adipokines which make the task of normal metabolic processes that much more difficult, mainly by disrupting the hormonal balance in your body. In other words, they sabotage the very processes you rely on to get rid of the fat. It's an insidious, self-preserving mechanism that left unchecked leads to further weight gain, and all the consequences to health that follow - which I'm sure I don't need to tell you about.

Hope that helps, but by all means check it with the doc. just to make sure I'm not talking out of the wrong hole!

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28 Oct 2014 00:42 #23855 by TheFastDoctor
TheFastDoctor replied the topic: Adipose toxicity
Thanks David, much appreciated.

Indeed Loquat, fat is dynamic but adipokines is part of our natural metabolism so it need not be toxic in physiolocially controlled concentrations. When one induces ketosis with a ketotic (high fat) diet then indeed the volumes may exceed the physiological boundaries (just like the ketones may, for example in diabetics) but when it is purely induced (and consumed again!) by fasting it is more physiological.

Heavy metals per se is of course not necessarily fat soluble as, like any metal (including Sodium and Potassium) they can become ionic and thus dissolve in water to be excreted by the kidneys. Most of the toxins that make us feel so groggy if we are not used to fasting, is organic chemicals such as synthetic colourants, flavourants, preservatives and some metabolites.

But dear Loquat, we tend for the sake of simplicity, simplify matters. In reality seldom are things clear cut! There are for example actually always at least some catabolism going... just not enough to fuel all your needs, like when fasting.


All my posts are "generic", based on my opinions and experiences only and are not intended to replace the advice of your own licensed medical practitioner.

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29 Oct 2014 16:49 #23877 by david
david replied the topic: Adipose toxicity
Thank you Doctor

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